KAT-Independent Gene Regulation by Tip60 Promotes ESC Self-Renewal but Not Pluripotency
Although histone-modifying enzymes are generally assumed to function in a manner dependent on their enzymatic activities, this assumption remains untested for many factors. Here, we show that the Tip60 (Kat5) lysine acetyltransferase (KAT), which is essential for embryonic stem cell (ESC) self-renew...
Main Authors: | Diwash Acharya, Sarah J. Hainer, Yeonsoo Yoon, Feng Wang, Ingolf Bach, Jaime A. Rivera-Pérez, Thomas G. Fazzio |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2017-04-01
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Series: | Cell Reports |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124717304606 |
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