The Infection Efficiency and Replication Ability of Circularized HBV DNA Optimized the Linear HBV DNA in Vitro and in Vivo

The Infection Efficiency and Replication Ability of Circularized HBV DNA Optimized the Linear HBV DNA in Vitro and in Vivo

Studies on molecular mechanisms of the persist infection of hepatitis B virus have been hampered by a lack of a robust animal model. We successfully established a simple, versatile, and reproducible HBV persist infection model in vitro and in vivo with the circularized HBV DNA. The cells and mice...

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Bibliographic Details
Main Authors: Xiaosong Li, Junke Zhu, Guoqi Lai, Lei Yan, Jieli Hu, Juan Chen, Ni Tang, Ailong Huang
Format: Article
Language:English
Published: MDPI AG 2015-03-01
Series:International Journal of Molecular Sciences
Subjects:
hepatitis B virus (HBV)
circularized HBV DNA
covalently closed circular DNA (cccDNA)
hepatocellular carcinoma (HCC)
persistent infection
viral replication
Online Access:http://www.mdpi.com/1422-0067/16/3/5141

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http://www.mdpi.com/1422-0067/16/3/5141

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