Targeting the DNA Repair Endonuclease ERCC1-XPF with Green Tea Polyphenol Epigallocatechin-3-Gallate (EGCG) and Its Prodrug to Enhance Cisplatin Efficacy in Human Cancer Cells

The 5′-3′ structure-specific endonuclease ERCC1/XPF (Excision Repair Cross-Complementation Group 1/Xeroderma Pigmentosum group F) plays critical roles in the repair of cisplatin-induced DNA damage. As such, it has been identified as a potential pharmacological target for enhancin...

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Bibliographic Details
Main Authors: Joshua R. Heyza, Sanjeevani Arora, Hao Zhang, Kayla L. Conner, Wen Lei, Ashley M. Floyd, Rahul R. Deshmukh, Jeffrey Sarver, Christopher J. Trabbic, Paul Erhardt, Tak-Hang Chan, Q. Ping Dou, Steve M. Patrick
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Nutrients
Subjects:
Online Access:https://www.mdpi.com/2072-6643/10/11/1644