Nucleolin reorganization and nucleolar stress in Purkinje cells of mutant PCD mice

Nucleolin reorganization and nucleolar stress in Purkinje cells of mutant PCD mice

The Purkinje cell (PC) degeneration (pcd) mouse harbors a mutation in Agtpbp1 gene that encodes for the cytosolic carboxypeptidase, CCP1. The mutation causes degeneration and death of PCs during the postnatal life, resulting in clinical and pathological manifestation of cerebellar ataxia. Monogenic...

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Bibliographic Details
Main Authors: Fernando C. Baltanás, María T. Berciano, Olga Tapia, Josep Oriol Narcis, Vanesa Lafarga, David Díaz, Eduardo Weruaga, Eugenio Santos, Miguel Lafarga
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Neurobiology of Disease
Subjects:
Agtpbp1
CCP1
Neurodegeneration
Nucleolar stress
Nucleolin
Purkinje cells
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119300713

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http://www.sciencedirect.com/science/article/pii/S0969996119300713

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