Curcumin derivative, 2,6-bis(2-fluorobenzylidene)cyclohexanone (MS65) inhibits interleukin-6 production through suppression of NF-κB and MAPK pathways in histamine-induced human keratinocytes cell (HaCaT)

Curcumin derivative, 2,6-bis(2-fluorobenzylidene)cyclohexanone (MS65) inhibits interleukin-6 production through suppression of NF-κB and MAPK pathways in histamine-induced human keratinocytes cell (HaCaT)

Abstract Background Histamine is a well-known mediator involved in skin allergic responses through up-regulation of pro-inflammatory cytokines. Antihistamines remain the mainstay of allergy treatment, but they were found limited in efficacy and associated with several common side effects. Therefore,...

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Bibliographic Details
Main Authors: Nurul Atika Razali, Nur Amiza Nazarudin, Kok Song Lai, Faridah Abas, Syahida Ahmad
Format: Article
Language:English
Published: BMC 2018-07-01
Series:BMC Complementary and Alternative Medicine
Subjects:
Histamine
Interleukin-6
Curcumin derivative
Keratinocytes
Online Access:http://link.springer.com/article/10.1186/s12906-018-2223-8

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http://link.springer.com/article/10.1186/s12906-018-2223-8

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