Hematopoietic ABCA1 deletion promotes monocytosis and worsens diet-induced insulin resistance in mice

Hematopoietic ABCA1 deletion promotes monocytosis and worsens diet-induced insulin resistance in mice

Low-grade chronic inflammation plays an important role in the pathogenesis of obesity-induced insulin resistance. ABCA1 is essential for reverse cholesterol transport and HDL synthesis, and protects against macrophage inflammation. In the present study, the effects of ABCA1 deficiency in hematopoiet...

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Bibliographic Details
Main Authors: Chongren Tang, Yuhua Liu, Wendy Yang, Carl Storey, Tim S. McMillen, Barbara A. Houston, Jay W. Heinecke, Renee C. LeBoeuf
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Journal of Lipid Research
Subjects:
cholesterol
adipose tissue
macrophages
high density lipoprotein
obesity
diabetes
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752031405X

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http://www.sciencedirect.com/science/article/pii/S002222752031405X

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