3,6’-dithiopomalidomide reduces neural loss, inflammation, behavioral deficits in brain injury and microglial activation

3,6’-dithiopomalidomide reduces neural loss, inflammation, behavioral deficits in brain injury and microglial activation

Traumatic brain injury (TBI) causes mortality and disability worldwide. It can initiate acute cell death followed by secondary injury induced by microglial activation, oxidative stress, inflammation and autophagy in brain tissue, resulting in cognitive and behavioral deficits. We evaluated a new pom...

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Bibliographic Details
Main Authors: Chih-Tung Lin, Daniela Lecca, Ling-Yu Yang, Weiming Luo, Michael T Scerba, David Tweedie, Pen-Sen Huang, Yoo-Jin Jung, Dong Seok Kim, Chih-Hao Yang, Barry J Hoffer, Jia-Yi Wang, Nigel H Greig
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-06-01
Series:eLife
Subjects:
traumatic brain injury
neuroinflammation
neurodegeneration
pomalidomide
3,6'-dithiopomalidomide
Online Access:https://elifesciences.org/articles/54726

Internet

https://elifesciences.org/articles/54726

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