Combined ATR and DNA-PK Inhibition Radiosensitizes Tumor Cells Independently of Their p53 Status

Combined ATR and DNA-PK Inhibition Radiosensitizes Tumor Cells Independently of Their p53 Status

Head and neck squamous cell carcinoma (HNSCC) is a significant cause of cancer deaths. Cisplatin-based chemoradiotherapy is a standard of care for locally advanced disease. ATR and DNA-PK inhibition (DNA-PKi) are actively being investigated in clinical trials with preclinical data supporting clinica...

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Bibliographic Details
Main Authors: Hind Hafsi, Magnus T. Dillon, Holly E. Barker, Joan N. Kyula, Ulrike Schick, James T. Paget, Henry G. Smith, Malin Pedersen, Martin McLaughlin, Kevin J. Harrington
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Oncology
Subjects:
DNA damage response
radiosensitization
checkpoint abrogation
mitotic catastrophe
ataxia telangiectasia- and RAD3-related
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00245/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2018.00245/full

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