Presymptomatic Treatment With Andrographolide Improves Brain Metabolic Markers and Cognitive Behavior in a Model of Early-Onset Alzheimer’s Disease

Presymptomatic Treatment With Andrographolide Improves Brain Metabolic Markers and Cognitive Behavior in a Model of Early-Onset Alzheimer’s Disease

Alzheimer’s disease (AD) is the most common type of dementia. The onset and progression of this pathology are correlated with several changes in the brain, including the formation of extracellular aggregates of amyloid-beta (Aβ) peptide and the intracellular accumulation of hyperphosphorylated tau p...

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Bibliographic Details
Main Authors: Pedro Cisternas, Carolina A. Oliva, Viviana I. Torres, Daniela P. Barrera, Nibaldo C. Inestrosa
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
andrographolide
Wnt signaling
glucose metabolism
Alzheimer’s disease
neuroprotection
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00295/full

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https://www.frontiersin.org/article/10.3389/fncel.2019.00295/full

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