Evaluation of the inverse electron demand Diels-Alder reaction in rats using a scandium-44-labelled tetrazine for pretargeted PET imaging

Evaluation of the inverse electron demand Diels-Alder reaction in rats using a scandium-44-labelled tetrazine for pretargeted PET imaging

Abstract Background Pretargeted imaging allows the use of short-lived radionuclides when imaging the accumulation of slow clearing targeting agents such as antibodies. The biotin-(strept)avidin and the bispecific antibody-hapten interactions have been applied in clinical pretargeting studies; unfort...

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Bibliographic Details
Main Authors: Patricia E. Edem, Jean-Philippe Sinnes, Stefanie Pektor, Nicole Bausbacher, Raffaella Rossin, Abdolreza Yazdani, Matthias Miederer, Andreas Kjær, John F. Valliant, Marc S. Robillard, Frank Rösch, Matthias M. Herth
Format: Article
Language:English
Published: SpringerOpen 2019-05-01
Series:EJNMMI Research
Subjects:
Scandium-44 (44Sc)
Positron emission tomography (PET)
Tetrazine
Trans-cyclooctene (TCO)
Pretargeted imaging
Inverse electron demand Diels-Alder (IEDDA)
Online Access:http://link.springer.com/article/10.1186/s13550-019-0520-y

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http://link.springer.com/article/10.1186/s13550-019-0520-y

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