Berberine Improves Glucose and Lipid Metabolism in HepG2 Cells Through AMPKα1 Activation

Berberine Improves Glucose and Lipid Metabolism in HepG2 Cells Through AMPKα1 Activation

AimThis study is designed to investigate whether or not AMP-activated protein kinase α1 (AMPKα1) is required for natural product berberine (BBR) to improve glucose and lipid metabolism in HepG2 cells.MethodsAMPKα1 knocked-out (KO, AMPKα1-/-) cells were obtained by co-transfection of the CRISPR/Cas9...

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Bibliographic Details
Main Authors: Gang Ren, Jiang-Hong Guo, Yu-Zhen Qian, Wei-Jia Kong, Jian-Dong Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
berberine
AMP-activated protein kinase α1
glucose consumption
gluconeogenesis
lipogenesis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00647/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00647/full

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