The role of GluN2A and GluN2B NMDA receptor subunits in AgRP and POMC neurons on body weight and glucose homeostasis

The role of GluN2A and GluN2B NMDA receptor subunits in AgRP and POMC neurons on body weight and glucose homeostasis

Objective: Hypothalamic agouti-related peptide (AgRP) and pro-opiomelanocortin (POMC) expressing neurons play critical roles in control of energy balance. Glutamatergic input via n-methyl-d-aspartate receptors (NMDARs) is pivotal for regulation of neuronal activity and is required in AgRP neurons fo...

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Bibliographic Details
Main Authors: Aykut Üner, Gabriel H.M. Gonçalves, Wenjing Li, Matheus Porceban, Nicole Caron, Milena Schönke, Eric Delpire, Kenji Sakimura, Christian Bjørbæk
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Molecular Metabolism
Subjects:
AgRP
NMDAR
GluN2B
Metabolism
Glycemia
Leptin
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877815001349

Internet

http://www.sciencedirect.com/science/article/pii/S2212877815001349

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