Dopamine-Induced Ascorbate Release From Retinal Neurons Involves Glutamate Release, Activation of AMPA/Kainate Receptors and Downstream Signaling Pathways

Dopamine-Induced Ascorbate Release From Retinal Neurons Involves Glutamate Release, Activation of AMPA/Kainate Receptors and Downstream Signaling Pathways

Ascorbate, the reduced form of Vitamin C, is one of the most abundant and important low-molecular weight antioxidants in living tissues. Most animals synthesize vitamin C, but some primates, including humans, have lost this capacity due to disruption in L-gulono-gamma-lactone oxidase gene. Because o...

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Bibliographic Details
Main Authors: Camila Cabral Portugal, Thaísa Godinho da Encarnação, Ivan Domith, Alexandre dos Santos Rodrigues, Nádia Almeida de Oliveira, Renato Socodato, Roberto Paes-de-Carvalho
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Neuroscience
Subjects:
SVCT2
vitamin C
D-aspartate
excitatory amino acid transporters
D1R
EPAC
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00453/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2019.00453/full

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