Decreased immunoglobulin G in brain regions of elder female APOE4-TR mice accompany with Aβ accumulation
Abstract Background Apolipoprotein E4 (APOE4) and ageing are the most important known risk factors for late-onset Alzheimer’s disease (AD). In the present study, we determined the alterations of IgG, CD19, and Aβ in various brain regions of uninfected male and female APOE3- and APOE4-TR mice at the...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2019-01-01
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Series: | Immunity & Ageing |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12979-018-0142-7 |