Decreased immunoglobulin G in brain regions of elder female APOE4-TR mice accompany with Aβ accumulation

Decreased immunoglobulin G in brain regions of elder female APOE4-TR mice accompany with Aβ accumulation

Abstract Background Apolipoprotein E4 (APOE4) and ageing are the most important known risk factors for late-onset Alzheimer’s disease (AD). In the present study, we determined the alterations of IgG, CD19, and Aβ in various brain regions of uninfected male and female APOE3- and APOE4-TR mice at the...

Full description

Bibliographic Details
Main Authors: Lihang Zhang, Juan Xu, Jinchao Gao, Peiqing Chen, Ming Yin, Wenjuan Zhao
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Immunity & Ageing
Subjects:
Immunoglobulin G
Apolipoprotein E4
Ageing
Alzheimer’s disease
Online Access:http://link.springer.com/article/10.1186/s12979-018-0142-7

Internet

http://link.springer.com/article/10.1186/s12979-018-0142-7

Similar Items