Multipotent Basal Stem Cells, Maintained in Localized Proximal Niches, Support Directed Long-Ranging Epithelial Flows in Human Prostates

Multipotent Basal Stem Cells, Maintained in Localized Proximal Niches, Support Directed Long-Ranging Epithelial Flows in Human Prostates

Sporadic mitochondrial DNA mutations serve as clonal marks providing access to the identity and lineage potential of stem cells within human tissues. By combining quantitative clonal mapping with 3D reconstruction of adult human prostates, we show that multipotent basal stem cells, confined to discr...

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Bibliographic Details
Main Authors: Mohammad Moad, Edouard Hannezo, Simon J. Buczacki, Laura Wilson, Amira El-Sherif, David Sims, Robert Pickard, Nicholas A. Wright, Stuart C. Williamson, Doug M. Turnbull, Robert W. Taylor, Laura Greaves, Craig N. Robson, Benjamin D. Simons, Rakesh Heer
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Cell Reports
Subjects:
stem cell
niche
prostate
epithelium
basal
luminal
branch
DLK1
Notch
organoids
prostate cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717310409

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http://www.sciencedirect.com/science/article/pii/S2211124717310409

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