Interpretation of genomic variants using a unified biological network approach.

The decreasing cost of sequencing is leading to a growing repertoire of personal genomes. However, we are lagging behind in understanding the functional consequences of the millions of variants obtained from sequencing. Global system-wide effects of variants in coding genes are particularly poorly u...

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Bibliographic Details
Main Authors: Ekta Khurana, Yao Fu, Jieming Chen, Mark Gerstein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC3591262?pdf=render