Single-dose mucosal immunization with a candidate universal influenza vaccine provides rapid protection from virulent H5N1, H3N2 and H1N1 viruses.

Single-dose mucosal immunization with a candidate universal influenza vaccine provides rapid protection from virulent H5N1, H3N2 and H1N1 viruses.

The sudden emergence of novel influenza viruses is a global public health concern. Conventional influenza vaccines targeting the highly variable surface glycoproteins hemagglutinin and neuraminidase must antigenically match the emerging strain to be effective. In contrast, "universal" vacc...

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Bibliographic Details
Main Authors: Graeme E Price, Mark R Soboleski, Chia-Yun Lo, Julia A Misplon, Mary R Quirion, Katherine V Houser, Melissa B Pearce, Claudia Pappas, Terrence M Tumpey, Suzanne L Epstein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2953831?pdf=render

Internet

http://europepmc.org/articles/PMC2953831?pdf=render

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