SIRT5 deacylates metabolism-related proteins and attenuates hepatic steatosis in ob/ob miceResearch in context

SIRT5 deacylates metabolism-related proteins and attenuates hepatic steatosis in ob/ob miceResearch in context

Background: Sirtuin 5 (SIRT5) is a NAD+-dependent lysine deacylase. The SIRT5 deficiency mouse model shows that it is dispensable for metabolic homeostasis under normal conditions. However, the biological role of SIRT5 and acylation in pathological states such as obesity and type 2 diabetes (T2D) re...

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Bibliographic Details
Main Authors: Yipeng Du, Hao Hu, Saisi Qu, Jifeng Wang, Chaoju Hua, Jialing Zhang, Peng Wei, Xiaolong He, Junfeng Hao, Pingsheng Liu, Fuquan Yang, Tingting Li, Taotao Wei
Format: Article
Language:English
Published: Elsevier 2018-10-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396418303955

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http://www.sciencedirect.com/science/article/pii/S2352396418303955

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