Immune monitoring in mesothelioma patients identifies novel immune-modulatory functions of gemcitabine associating with clinical response

Immune monitoring in mesothelioma patients identifies novel immune-modulatory functions of gemcitabine associating with clinical response

Background: Gemcitabine is a frequently used chemotherapeutic agent but its effects on the immune system are incompletely understood. Recently, the randomized NVALT19-trial revealed that maintenance gemcitabine after first-line chemotherapy significantly prolonged progression-free survival (PFS) com...

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Bibliographic Details
Main Authors: Floris Dammeijer, Cornedine J. De Gooijer, Mandy van Gulijk, Melanie Lukkes, Larissa Klaase, Lysanne A. Lievense, Cynthia Waasdorp, Merel Jebbink, Gerben P. Bootsma, Jos A. Stigt, Bonne Biesma, Margaretha E.H. Kaijen-Lambers, Joanne Mankor, Heleen Vroman, Robin Cornelissen, Paul Baas, Vincent Van der Noort, Jacobus A. Burgers, Joachim G. Aerts
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:EBioMedicine
Subjects:
Malignant mesothelioma
Lymphocytes
Myeloid-derived suppressor cells
Gemcitabine
Immunotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420305363

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http://www.sciencedirect.com/science/article/pii/S2352396420305363

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