Lack of avidity maturation of merozoite antigen-specific antibodies with increasing exposure to Plasmodium falciparum amongst children and adults exposed to endemic malaria in Kenya.

Lack of avidity maturation of merozoite antigen-specific antibodies with increasing exposure to Plasmodium falciparum amongst children and adults exposed to endemic malaria in Kenya.

BACKGROUND:Although antibodies are critical for immunity to malaria, their functional attributes that determine protection remain unclear. We tested for associations between antibody avidities to Plasmodium falciparum (Pf) antigens and age, asymptomatic parasitaemia, malaria exposure index (a distan...

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Bibliographic Details
Main Authors: Frances Ibison, Ally Olotu, Daniel M Muema, Jedida Mwacharo, Eric Ohuma, Domtila Kimani, Kevin Marsh, Philip Bejon, Francis M Ndungu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3530478?pdf=render

Internet

http://europepmc.org/articles/PMC3530478?pdf=render

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