CK2 Phosphorylating I2PP2A/SET Mediates Tau Pathology and Cognitive Impairment

CK2 Phosphorylating I2PP2A/SET Mediates Tau Pathology and Cognitive Impairment

Casein kinase 2 (CK2) is highly activated in Alzheimer disease (AD) and is associated with neurofibrillary tangles formation. Phosphorylated SET, a potent PP2A inhibitor, mediates tau hyperphosphorylation in AD. However, whether CK2 phosphorylates SET and regulates tau pathological phosphorylation i...

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Bibliographic Details
Main Authors: Qing Zhang, Yiyuan Xia, Yongjun Wang, Yangping Shentu, Kuan Zeng, Yacoubou A. R. Mahaman, Fang Huang, Mengjuan Wu, Dan Ke, Qun Wang, Bin Zhang, Rong Liu, Jian-Zhi Wang, Keqiang Ye, Xiaochuan Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
casein kinase 2 (CK2)
Alzheimer disease (AD)
SET
tau phosphorylation
cognitive impairment
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2018.00146/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2018.00146/full

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