Prenatal correction of IGF2 to rescue the growth phenotypes in mouse models of Beckwith-Wiedemann and Silver-Russell syndromes

Prenatal correction of IGF2 to rescue the growth phenotypes in mouse models of Beckwith-Wiedemann and Silver-Russell syndromes

Summary: Beckwith-Wiedemann syndrome (BWS) and Silver-Russell syndrome (SRS) are imprinting disorders manifesting as aberrant fetal growth and severe postnatal-growth-related complications. Based on the insulator model, one-third of BWS cases and two-thirds of SRS cases are consistent with misexpres...

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Bibliographic Details
Main Authors: Ji Liao, Tie-Bo Zeng, Nicholas Pierce, Diana A. Tran, Purnima Singh, Jeffrey R. Mann, Piroska E. Szabó
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Cell Reports
Subjects:
IGF2
genomic imprinting
imprinting disorder
Beckwith-Wiedemann syndrome
Silver-Russell syndrome
amniotic fluid
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721000425

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http://www.sciencedirect.com/science/article/pii/S2211124721000425

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