Neuronal activity-induced BRG1 phosphorylation regulates enhancer activation

Neuronal activity-induced BRG1 phosphorylation regulates enhancer activation

Summary: Neuronal activity-induced enhancers drive gene activation. We demonstrate that BRG1, the core subunit of SWI/SNF-like BAF ATP-dependent chromatin remodeling complexes, regulates neuronal activity-induced enhancers. Upon stimulation, BRG1 is recruited to enhancers in an H3K27Ac-dependent man...

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Bibliographic Details
Main Authors: BongWoo Kim, Yi Luo, Xiaoming Zhan, Zilai Zhang, Xuanming Shi, Jiaqing Yi, Zhenyu Xuan, Jiang Wu
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Cell Reports
Subjects:
neuronal activity-regulated genes
enhancer
chromatin remodeling
BRG1/SMARCA4
phosphorylation
enhancer-promoter looping
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721007555

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http://www.sciencedirect.com/science/article/pii/S2211124721007555

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