Inflammation dependent mTORC1 signaling interferes with the switch from keratinocyte proliferation to differentiation.

Inflammation dependent mTORC1 signaling interferes with the switch from keratinocyte proliferation to differentiation.

Psoriasis is a frequent and often severe inflammatory skin disease, characterized by altered epidermal homeostasis. Since we found previously that Akt/mTOR signaling is hyperactivated in psoriatic skin, we aimed at elucidating the role of aberrant mTORC1 signaling in this disease. We found that unde...

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Bibliographic Details
Main Authors: Claudia Buerger, Nitesh Shirsath, Victoria Lang, Alina Berard, Sandra Diehl, Roland Kaufmann, Wolf-Henning Boehncke, Peter Wolf
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5507280?pdf=render

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http://europepmc.org/articles/PMC5507280?pdf=render

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