The Gαi protein subclass selectivity to the dopamine D2 receptor is also decided by their location at the cell membrane
Abstract Background G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins plays an important role in the cellular regulation of responses to external stimuli. Despite intensive structural research, the mechanism underlying the receptor–G protein coupling of closely related subtyp...
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2020-12-01
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Series: | Cell Communication and Signaling |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12964-020-00685-9 |