The Gαi protein subclass selectivity to the dopamine D2 receptor is also decided by their location at the cell membrane

The Gαi protein subclass selectivity to the dopamine D2 receptor is also decided by their location at the cell membrane

Abstract Background G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins plays an important role in the cellular regulation of responses to external stimuli. Despite intensive structural research, the mechanism underlying the receptor–G protein coupling of closely related subtyp...

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Bibliographic Details
Main Authors: Agnieszka Polit, Beata Rysiewicz, Paweł Mystek, Ewa Błasiak, Marta Dziedzicka-Wasylewska
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Cell Communication and Signaling
Subjects:
Heterotrimeric G proteins
Dopamine D2 receptor
Functional selectivity
Protein–membrane interaction
FLIM–FRET
FRAP
Online Access:https://doi.org/10.1186/s12964-020-00685-9

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