Synthesis of New 1, 3, 4-Oxadiazole-Incorporated 1, 2, 3-Triazole Moieties as Potential Anticancer Agents Targeting Thymidylate Synthase and Their Docking Studies

Synthesis of New 1, 3, 4-Oxadiazole-Incorporated 1, 2, 3-Triazole Moieties as Potential Anticancer Agents Targeting Thymidylate Synthase and Their Docking Studies

Thymidylate synthase (TS) has emerged as a hot spot in cancer treatment, as it is directly involved in DNA synthesis. In the present article, nine hybrids containing 1,2,3-triazole and 1,3,4-oxadiazole moieties (<b>6</b>–<b>14</b>) were synthesized and evaluated for anticance...

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Bibliographic Details
Main Authors: Mohammad Mahboob Alam, Abdulraheem SA Almalki, Thikryat Neamatallah, Nada M. Ali, Azizah M. Malebari, Syed Nazreen
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Pharmaceuticals
Subjects:
thymidylate synthase
cytotoxicity
1,2,3-triazole
1,3,4-oxadiazole
5-fluoruracil
pemetrexed
Online Access:https://www.mdpi.com/1424-8247/13/11/390

Internet

https://www.mdpi.com/1424-8247/13/11/390

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