Participation of NADPH Oxidase-Related Reactive Oxygen Species in Leptin-Promoted Pulmonary Inflammation: Regulation of cPLA2α and COX-2 Expression

Participation of NADPH Oxidase-Related Reactive Oxygen Species in Leptin-Promoted Pulmonary Inflammation: Regulation of cPLA2α and COX-2 Expression

Obesity is a worldwide epidemic problem and correlates to varieties of acute or chronic lung diseases such as acute respiratory distress syndrome, chronic obstructive pulmonary disease, and pulmonary fibrosis. An increase of leptin, a kind of adipokine, in lean mice plasma has been found to impair i...

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Bibliographic Details
Main Authors: Pei-Sung Hsu, Chia-Mo Lin, Jia-Feng Chang, Chi-Sheng Wu, Kee-Chin Sia, I-Ta Lee, Kuo-Yang Huang, Wei-Ning Lin
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
leptin
cPLA2α
COX-2
ROS
c-Jun
inflammation
Online Access:http://www.mdpi.com/1422-0067/20/5/1078

Internet

http://www.mdpi.com/1422-0067/20/5/1078

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