Genetic disruption of WASHC4 drives endo-lysosomal dysfunction and cognitive-movement impairments in mice and humans

Genetic disruption of WASHC4 drives endo-lysosomal dysfunction and cognitive-movement impairments in mice and humans

Mutation of the Wiskott–Aldrich syndrome protein and SCAR homology (WASH) complex subunit, SWIP, is implicated in human intellectual disability, but the cellular etiology of this association is unknown. We identify the neuronal WASH complex proteome, revealing a network of endosomal proteins. To unc...

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Bibliographic Details
Main Authors: Jamie L Courtland, Tyler WA Bradshaw, Greg Waitt, Erik J Soderblom, Tricia Ho, Anna Rajab, Ricardo Vancini, Il Hwan Kim, Scott H Soderling
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-03-01
Series:eLife
Subjects:
endosome
lysosome
proteomics
WASH complex
SWIP
motor impairment
Online Access:https://elifesciences.org/articles/61590

Internet

https://elifesciences.org/articles/61590

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