Impairments in cognition and neural precursor cell proliferation in mice expressing constitutively active glycogen synthase kinase-3

Impairments in cognition and neural precursor cell proliferation in mice expressing constitutively active glycogen synthase kinase-3

ABSTRACTBrain glycogen synthase kinase-3 (GSK3) is hyperactive in several neurological conditions that involve impairments in both cognition and neurogenesis. This raises the hypotheses that hyperactive GSK3 may directly contribute to impaired cognition, and that this may be related to deficiencies...

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Bibliographic Details
Main Authors: Marta ePardo, Margaret K. King, EMMA ePEREZ-COSTAS, Miguel eMelendez-Ferro, Ana eMartinez, Eleonore eBeurel, Richard Scott Jope
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-03-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Neurogenesis
spatial memory
environmental enrichment
Glycogen Synthase Kinase-3
Novel object recognition
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00055/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00055/full

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