Impairments in cognition and neural precursor cell proliferation in mice expressing constitutively active glycogen synthase kinase-3
ABSTRACTBrain glycogen synthase kinase-3 (GSK3) is hyperactive in several neurological conditions that involve impairments in both cognition and neurogenesis. This raises the hypotheses that hyperactive GSK3 may directly contribute to impaired cognition, and that this may be related to deficiencies...
Main Authors: | Marta ePardo, Margaret K. King, EMMA ePEREZ-COSTAS, Miguel eMelendez-Ferro, Ana eMartinez, Eleonore eBeurel, Richard Scott Jope |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2015-03-01
|
Series: | Frontiers in Behavioral Neuroscience |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00055/full |
Similar Items
-
Glycogen synthase kinase-3 in the etiology and treatment of mood disorders
by: Richard Scott Jope
Published: (2011-08-01) -
Structure and regulation of yeast glycogen synthase
by: Baskaran, Sulochanadevi
Published: (2010) -
Regulation by glycogen synthase kinase-3 of inflammation and T cells in CNS diseases
by: Eleonore eBeurel
Published: (2011-08-01) -
Proteomic analysis in glycogen synthase Kinase 3 inhibition and activation cell models.
Published: (2007) -
Structural basis for regulated inhibition and substrate selection in yeast glycogen synthase
by: Mahalingan, Krishna Kishore
Published: (2017)