Type 1 Diabetes Mellitus-Associated Genetic Variants Contribute to Overlapping Immune Regulatory Networks

Type 1 Diabetes Mellitus-Associated Genetic Variants Contribute to Overlapping Immune Regulatory Networks

Type 1 diabetes (T1D) is a chronic metabolic disorder characterized by the autoimmune destruction of insulin-producing pancreatic islet beta cells in genetically predisposed individuals. Genome-wide association studies (GWAS) have identified over 60 risk regions across the human genome, marked by si...

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Bibliographic Details
Main Authors: Denis M. Nyaga, Mark H. Vickers, Craig Jefferies, Jo K. Perry, Justin M. O’Sullivan
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Genetics
Subjects:
Type 1 diabetes
genome-wide association studies (GWAS)
genetic variation
genome organization
expression quantitative trait loci (eQTL)
autoimmunity
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2018.00535/full

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https://www.frontiersin.org/article/10.3389/fgene.2018.00535/full

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