High WT1 expression is an early predictor for relapse in patients with acute promyelocytic leukemia in first remission with negative PML-RARa after anthracycline-based chemotherapy: a single-center cohort study

High WT1 expression is an early predictor for relapse in patients with acute promyelocytic leukemia in first remission with negative PML-RARa after anthracycline-based chemotherapy: a single-center cohort study

Abstract Wilms’ tumor gene 1 (WT1) expression is a well-known predictor for relapse in acute myeloid leukemia. We monitored WT1 decrement along the treatment course to identify its significant role as a marker for residual disease in acute promyelocytic leukemia (APL) and tried to suggest its signif...

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Bibliographic Details
Main Authors: Jae-Ho Yoon, Hee-Je Kim, Dae-Hun Kwak, Sung-Soo Park, Young-Woo Jeon, Sung-Eun Lee, Byung-Sik Cho, Ki-Seong Eom, Yoo-Jin Kim, Seok Lee, Chang-Ki Min, Seok-Goo Cho, Dong-Wook Kim, Jong Wook Lee, Woo-Sung Min
Format: Article
Language:English
Published: BMC 2017-01-01
Series:Journal of Hematology & Oncology
Subjects:
Acute promyelocytic leukemia
WT1
FLT3 mutation
Minimal residual disease
Online Access:http://link.springer.com/article/10.1186/s13045-017-0404-4

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http://link.springer.com/article/10.1186/s13045-017-0404-4

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