Cutting Edge PBPK Models and Analyses: Providing the Basis for Future Modeling Efforts and Bridges to Emerging Toxicology Paradigms

Physiologically based Pharmacokinetic (PBPK) models are used for predictions of internal or target dose from environmental and pharmacologic chemical exposures. Their use in human risk assessment is dependent on the nature of databases (animal or human) used to develop and test them, and includes ex...

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Bibliographic Details
Main Authors: Jane C. Caldwell, Marina V. Evans, Kannan Krishnan
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Journal of Toxicology
Online Access:http://dx.doi.org/10.1155/2012/852384