Loss of Mucosal p32/gC1qR/HABP1 Triggers Energy Deficiency and Impairs Goblet Cell Differentiation in Ulcerative ColitisSummary

Loss of Mucosal p32/gC1qR/HABP1 Triggers Energy Deficiency and Impairs Goblet Cell Differentiation in Ulcerative ColitisSummary

Background & Aims: Cell differentiation in the colonic crypt is driven by a metabolic switch from glycolysis to mitochondrial oxidation. Mitochondrial and goblet cell dysfunction have been attributed to the pathology of ulcerative colitis (UC). We hypothesized that p32/gC1qR/HABP1, which cri...

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Bibliographic Details
Main Authors: Annika Sünderhauf, Maren Hicken, Heidi Schlichting, Kerstin Skibbe, Mohab Ragab, Annika Raschdorf, Misa Hirose, Holger Schäffler, Arne Bokemeyer, Dominik Bettenworth, Anne G. Savitt, Sven Perner, Saleh Ibrahim, Ellinor I. Peerschke, Berhane Ghebrehiwet, Stefanie Derer, Christian Sina
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Mitochondrial Function
C1QBP
Inflammatory Bowel Disease
Mucus Barrier
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X21000230

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http://www.sciencedirect.com/science/article/pii/S2352345X21000230

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