LET-502/ROCK Regulates Endocytic Recycling by Promoting Activation of RAB-5 in a Distinct Subpopulation of Sorting Endosomes

LET-502/ROCK Regulates Endocytic Recycling by Promoting Activation of RAB-5 in a Distinct Subpopulation of Sorting Endosomes

Summary: To explore the mechanism of Rab5/RAB-5 activation during endocytic recycling, we perform a genome-wide RNAi screen and identify a recycling regulator, LET-502/ROCK. LET-502 preferentially interacts with RAB-5(GDP) and activates RABX-5 GEF activity toward RAB-5, presumably by disrupting the...

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Bibliographic Details
Main Authors: Wenjuan Zhang, Shimin Wang, Chao Yang, Can Hu, Dan Chen, Qian Luo, Zhen He, Yuhan Liao, Yuxin Yao, Juan Chen, Jun He, Junbo Hu, Tian Xia, Long Lin, Anbing Shi
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Cell Reports
Subjects:
C. elegans
endocytic recycling
RAB-5/Rab5
LET-502/ROCK
CED-10/Rac1
RABX-5
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720311621

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http://www.sciencedirect.com/science/article/pii/S2211124720311621

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