Investigating the Interaction of Cyclic RGD Peptidomimetics with αVβ6 Integrin by Biochemical and Molecular Docking Studies

Investigating the Interaction of Cyclic RGD Peptidomimetics with αVβ6 Integrin by Biochemical and Molecular Docking Studies

The interaction of a small library of cyclic RGD (Arg-Gly-Asp) peptidomimetics with αVβ6 integrin has been investigated by means of competitive solid phase binding assays to the isolated receptor and docking calculations in the crystal structure of the αVβ6 binding site. To this aim, a rigid recepto...

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Bibliographic Details
Main Authors: Monica Civera, Daniela Arosio, Francesca Bonato, Leonardo Manzoni, Luca Pignataro, Simone Zanella, Cesare Gennari, Umberto Piarulli, Laura Belvisi
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:Cancers
Subjects:
RGD peptidomimetics
integrins
molecular docking
binding assays
Online Access:https://www.mdpi.com/2072-6694/9/10/128

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https://www.mdpi.com/2072-6694/9/10/128

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