Intracellular calcium leak lowers glucose storage in human muscle, promoting hyperglycemia and diabetes

Intracellular calcium leak lowers glucose storage in human muscle, promoting hyperglycemia and diabetes

Most glucose is processed in muscle, for energy or glycogen stores. Malignant Hyperthermia Susceptibility (MHS) exemplifies muscle conditions that increase [Ca2+]cytosol. 42% of MHS patients have hyperglycemia. We show that phosphorylated glycogen phosphorylase (GPa), glycogen synthase (GSa) – respe...

Full description

Bibliographic Details
Main Authors: Eshwar R Tammineni, Natalia Kraeva, Lourdes Figueroa, Carlo Manno, Carlos A Ibarra, Amira Klip, Sheila Riazi, Eduardo Rios
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-05-01
Series:eLife
Subjects:
muscle fiber
malignant hyperthermia
ryanodine receptor
glycogen phosphorylase
diabetes
Online Access:https://elifesciences.org/articles/53999

Internet

https://elifesciences.org/articles/53999

Similar Items