SOX9 Knockout Induces Polyploidy and Changes Sensitivity to Tumor Treatment Strategies in a Chondrosarcoma Cell Line

SOX9 Knockout Induces Polyploidy and Changes Sensitivity to Tumor Treatment Strategies in a Chondrosarcoma Cell Line

As most chemotherapeutic drugs are ineffective in the treatment of chondrosarcoma, we studied the expression pattern and function of SOX9, the master transcription factor for chondrogenesis, in chondrosarcoma, to understand the basic molecular principles needed for engineering new targeted therapies...

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Bibliographic Details
Main Authors: Sabine Stöckl, Georg Lindner, Shushan Li, Philipp Schuster, Sebastian Haferkamp, Ferdinand Wagner, Peter M. Prodinger, Gabriele Multhoff, Melanie Boxberg, Axel Hillmann, Richard J. Bauer, Susanne Grässel
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
SOX9
transcription factor
chondrosarcoma
polyploidy
MMP13
CRISPR/Cas9
Online Access:https://www.mdpi.com/1422-0067/21/20/7627

Internet

https://www.mdpi.com/1422-0067/21/20/7627

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