Cardioprotective Effects of PPARβ/δ Activation against Ischemia/Reperfusion Injury in Rat Heart Are Associated with ALDH2 Upregulation, Amelioration of Oxidative Stress and Preservation of Mitochondrial Energy Production

Cardioprotective Effects of PPARβ/δ Activation against Ischemia/Reperfusion Injury in Rat Heart Are Associated with ALDH2 Upregulation, Amelioration of Oxidative Stress and Preservation of Mitochondrial Energy Production

Accumulating evidence support the cardioprotective properties of the nuclear receptor peroxisome proliferator activated receptor β/δ (PPARβ/δ); however, the underlying mechanisms are not yet fully elucidated. The aim of the study was to further investigate the mechanisms underlying PPARβ/δ-mediated...

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Bibliographic Details
Main Authors: Ioanna Papatheodorou, Eleftheria Galatou, Georgios-Dimitrios Panagiotidis, Táňa Ravingerová, Antigone Lazou
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
ischemia/reperfusion
oxidative stress
ALDH2
PPARβ/δ
mitochondria
Online Access:https://www.mdpi.com/1422-0067/22/12/6399

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https://www.mdpi.com/1422-0067/22/12/6399

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