Murine Myocardial Transcriptome Analysis Reveals a Critical Role of COPS8 in the Gene Expression of Cullin-RING Ligase Substrate Receptors and Redox and Vesicle Trafficking Pathways

Murine Myocardial Transcriptome Analysis Reveals a Critical Role of COPS8 in the Gene Expression of Cullin-RING Ligase Substrate Receptors and Redox and Vesicle Trafficking Pathways

Background: The COP9 signalosome (CSN) consisting of 8 unique protein subunits (COPS1 through COPS8) serves as the cullin deneddylase, regulating the catalytic dynamics of cullin RING ligases (CRLs), the largest family of ubiquitin ligases Background: The COP9 signalosome (CSN) consisting of 8 uniqu...

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Bibliographic Details
Main Authors: Ammara Abdullah, Kathleen M. Eyster, Travis Bjordahl, Peng Xiao, Erliang Zeng, Xuejun Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Physiology
Subjects:
the COP9 signalosome
transcription profiling
myocardium
COPS8 gene
conditional gene targeting
cullin-RING ligases
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00594/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2017.00594/full

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