Targeting chemokines for acute lymphoblastic leukemia therapy
Abstract Acute lymphoblastic leukemia (ALL) is a hematological malignancy characterized by the malignant clonal expansion of lymphoid hematopoietic precursors. It is regulated by various signaling molecules such as cytokines and adhesion molecules in its microenvironment. Chemokines are chemotactic...
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doaj-3ca7b9c1d1e243969068bf01c28093a92021-03-21T12:03:35ZengBMCJournal of Hematology & Oncology1756-87222021-03-0114111410.1186/s13045-021-01060-yTargeting chemokines for acute lymphoblastic leukemia therapyZixi Hong0Zimeng Wei1Tian Xie2Lin Fu3Jiaxing Sun4Fuling Zhou5Muhammad Jamal6Qiuping Zhang7Liang Shao8Department of Hematology, Zhongnan Hospital of Wuhan UniversityDepartment of Immunology, School of Basic Medical Science, Wuhan UniversityDepartment of Immunology, School of Basic Medical Science, Wuhan UniversityThe First Clinical School of Wuhan UniversityDepartment of Immunology, School of Basic Medical Science, Wuhan UniversityDepartment of Hematology, Zhongnan Hospital of Wuhan UniversityDepartment of Immunology, School of Basic Medical Science, Wuhan UniversityDepartment of Immunology, School of Basic Medical Science, Wuhan UniversityDepartment of Hematology, Zhongnan Hospital of Wuhan UniversityAbstract Acute lymphoblastic leukemia (ALL) is a hematological malignancy characterized by the malignant clonal expansion of lymphoid hematopoietic precursors. It is regulated by various signaling molecules such as cytokines and adhesion molecules in its microenvironment. Chemokines are chemotactic cytokines that regulate migration, positioning and interactions of cells. Many chemokine axes such as CXCL12/CXCR4 and CCL25/CCR9 have been proved to play important roles in leukemia microenvironment and further affect ALL outcomes. In this review, we summarize the chemokines that are involved in ALL progression and elaborate on their roles and mechanisms in leukemia cell proliferation, infiltration, drug resistance and disease relapse. We also discuss the potential of targeting chemokine axes for ALL treatments, since many related inhibitors have shown promising efficacy in preclinical trials, and some of them have entered clinical trials.https://doi.org/10.1186/s13045-021-01060-yAcute lymphoblastic leukemiaChemokineMicroenvironmentTherapeutic targets |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zixi Hong Zimeng Wei Tian Xie Lin Fu Jiaxing Sun Fuling Zhou Muhammad Jamal Qiuping Zhang Liang Shao |
spellingShingle |
Zixi Hong Zimeng Wei Tian Xie Lin Fu Jiaxing Sun Fuling Zhou Muhammad Jamal Qiuping Zhang Liang Shao Targeting chemokines for acute lymphoblastic leukemia therapy Journal of Hematology & Oncology Acute lymphoblastic leukemia Chemokine Microenvironment Therapeutic targets |
author_facet |
Zixi Hong Zimeng Wei Tian Xie Lin Fu Jiaxing Sun Fuling Zhou Muhammad Jamal Qiuping Zhang Liang Shao |
author_sort |
Zixi Hong |
title |
Targeting chemokines for acute lymphoblastic leukemia therapy |
title_short |
Targeting chemokines for acute lymphoblastic leukemia therapy |
title_full |
Targeting chemokines for acute lymphoblastic leukemia therapy |
title_fullStr |
Targeting chemokines for acute lymphoblastic leukemia therapy |
title_full_unstemmed |
Targeting chemokines for acute lymphoblastic leukemia therapy |
title_sort |
targeting chemokines for acute lymphoblastic leukemia therapy |
publisher |
BMC |
series |
Journal of Hematology & Oncology |
issn |
1756-8722 |
publishDate |
2021-03-01 |
description |
Abstract Acute lymphoblastic leukemia (ALL) is a hematological malignancy characterized by the malignant clonal expansion of lymphoid hematopoietic precursors. It is regulated by various signaling molecules such as cytokines and adhesion molecules in its microenvironment. Chemokines are chemotactic cytokines that regulate migration, positioning and interactions of cells. Many chemokine axes such as CXCL12/CXCR4 and CCL25/CCR9 have been proved to play important roles in leukemia microenvironment and further affect ALL outcomes. In this review, we summarize the chemokines that are involved in ALL progression and elaborate on their roles and mechanisms in leukemia cell proliferation, infiltration, drug resistance and disease relapse. We also discuss the potential of targeting chemokine axes for ALL treatments, since many related inhibitors have shown promising efficacy in preclinical trials, and some of them have entered clinical trials. |
topic |
Acute lymphoblastic leukemia Chemokine Microenvironment Therapeutic targets |
url |
https://doi.org/10.1186/s13045-021-01060-y |
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