Neddylation activity modulates the neurodegeneration associated with fragile X associated tremor/ataxia syndrome (FXTAS) through regulating Sima

Neddylation activity modulates the neurodegeneration associated with fragile X associated tremor/ataxia syndrome (FXTAS) through regulating Sima

Fragile X associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder caused by expansion of CGG repeats in the 5’ UTR of the fragile X mental retardation 1 (FMR1) gene. Using the well-established FXTAS Drosophila model, we performed a high-throughput chemical screen using 3...

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Bibliographic Details
Main Authors: Yunting Lin, Jin Xue, Jing Deng, Hua He, Shiyu Luo, Jia Chen, Jia Li, Li Yu, Juan Zhao, Jing Chen, Emily G. Allen, Peng Jin, Ranhui Duan
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Neurobiology of Disease
Subjects:
FXTAS
Drosophila
Chemical screen
Neddylation
HIF1α/Sima
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120302886

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http://www.sciencedirect.com/science/article/pii/S0969996120302886

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