Transcriptional Signatures of Tau and Amyloid Neuropathology

Transcriptional Signatures of Tau and Amyloid Neuropathology

Summary: Alzheimer’s disease (AD) is associated with the intracellular aggregation of hyperphosphorylated tau and the accumulation of β-amyloid in the neocortex. We use transgenic mice harboring human tau (rTg4510) and amyloid precursor protein (J20) mutations to investigate transcriptional changes...

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Main Authors: Isabel Castanho, Tracey K. Murray, Eilis Hannon, Aaron Jeffries, Emma Walker, Emma Laing, Hedley Baulf, Joshua Harvey, Lauren Bradshaw, Andrew Randall, Karen Moore, Paul O’Neill, Katie Lunnon, David A. Collier, Zeshan Ahmed, Michael J. O’Neill, Jonathan Mill
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720300887

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http://www.sciencedirect.com/science/article/pii/S2211124720300887

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