Interplay of Matrix Stiffness and c-SRC in Hepatic Fibrosis.

Interplay of Matrix Stiffness and c-SRC in Hepatic Fibrosis.

Introduction:In liver fibrosis activation of hepatic stellate cells (HSC) comprises phenotypical change into profibrotic and myofibroplastic cells with increased contraction and secretion of extracellular matrix (ECM) proteins. The small GTPase RhoA orchestrates cytoskeleton formation, migration and...

Full description

Bibliographic Details
Main Authors: Jan eGörtzen, Robert eSchierwagen, Jeanette eBierwolf, Sabine eKlein, Frank Erhard Uschner, Peter F. van der Ven, Dieter O. Fürst, Christian P. Strassburg, Wim eLaleman, Jörg-Matthias ePollok, Jonel eTrebicka
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-12-01
Series:Frontiers in Physiology
Subjects:
Hepatic Stellate Cells
RhoA
src
liver fibrosis
PP2
Matrix stiffness
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00359/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00359/full

Similar Items