BDNF-Live-Exon-Visualization (BLEV) Allows Differential Detection of BDNF Transcripts in vitro and in vivo

BDNF-Live-Exon-Visualization (BLEV) Allows Differential Detection of BDNF Transcripts in vitro and in vivo

Bdnf exon-IV and exon-VI transcripts are driven by neuronal activity and are involved in pathologies related to sleep, fear or memory disorders. However, how their differential transcription translates activity changes into long-lasting network changes is elusive. Aiming to trace specifically the ne...

Full description

Bibliographic Details
Main Authors: Wibke Singer, Marie Manthey, Rama Panford-Walsh, Lucas Matt, Hyun-Soon Geisler, Eleonora Passeri, Gabriele Baj, Enrico Tongiorgi, Graciano Leal, Carlos B. Duarte, Ivan L. Salazar, Philipp Eckert, Karin Rohbock, Jing Hu, Jörg Strotmann, Peter Ruth, Ulrike Zimmermann, Lukas Rüttiger, Thomas Ott, Thomas Schimmang, Marlies Knipper
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
BDNF detection
Bdnf exon-IV and -VI
transgenic BDNF reporter mice
activity-dependent BDNF expression
long-lasting plasticity changes
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00325/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2018.00325/full

Similar Items