Evidence of Destabilization of the Human Thymidylate Synthase (hTS) Dimeric Structure Induced by the Interface Mutation Q62R

Evidence of Destabilization of the Human Thymidylate Synthase (hTS) Dimeric Structure Induced by the Interface Mutation Q62R

In human cells, thymidylate synthase (TS) provides the only source of 2′-deoxythymidyne-5′-monophosphate (dTMP), which is required for DNA biosynthesis. Because of its pivotal role, human TS (hTS) represents a validated target for anticancer chemotherapy. Nonetheless, the efficac...

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Bibliographic Details
Main Authors: Cecilia Pozzi, Ludovica Lopresti, Matteo Santucci, Maria Paola Costi, Stefano Mangani
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Biomolecules
Subjects:
human thymidylate synthase
interface variant
dimer destabilization
circular dichroism
thermal stability
X-ray crystallography
site-directed mutagenesis
Online Access:https://www.mdpi.com/2218-273X/9/4/134

Internet

https://www.mdpi.com/2218-273X/9/4/134

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