Deletion of intestinal epithelial AMP-activated protein kinase alters distal colon permeability but not glucose homeostasis

Deletion of intestinal epithelial AMP-activated protein kinase alters distal colon permeability but not glucose homeostasis

Objective: The intestinal epithelial barrier (IEB) restricts the passage of microbes and potentially harmful substances from the lumen through the paracellular space, and rupture of its integrity is associated with a variety of gastrointestinal disorders and extra-digestive diseases. Increased IEB p...

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Bibliographic Details
Main Authors: Séverine Olivier, Camille Pochard, Hanna Diounou, Vanessa Castillo, Jordane Divoux, Joshua Alcantara, Jocelyne Leclerc, Sandra Guilmeau, Camille Huet, Wafa Charifi, Thibault V. Varin, Noëmie Daniel, Marc Foretz, Michel Neunlist, Benoit L. Salomon, Pradipta Ghosh, André Marette, Malvyne Rolli-Derkinderen, Benoit Viollet
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Molecular Metabolism
Subjects:
AMPK
Intestinal epithelial barrier (IEB)
Permeability
Microbiota
Obesity
Metformin
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877821000235

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http://www.sciencedirect.com/science/article/pii/S2212877821000235

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