Gene-Wise Burden of Coding Variants Correlates to Noncoding Pharmacogenetic Risk Variants

Gene-Wise Burden of Coding Variants Correlates to Noncoding Pharmacogenetic Risk Variants

Genetic variability can modulate individual drug responses. A significant portion of pharmacogenetic variants reside in the noncoding genome yet it is unclear if the noncoding variants directly influence protein function and expression or are present on a haplotype including a functionally relevant...

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Bibliographic Details
Main Authors: Jihye Park, Soo Youn Lee, Su Youn Baik, Chan Hee Park, Jun Hee Yoon, Brian Y. Ryu, Ju Han Kim
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
drug response
genetic variability
deleterious sequence variant
pharmacogenomics
pharmacogenetics
next generation sequencing
Online Access:https://www.mdpi.com/1422-0067/21/9/3091

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https://www.mdpi.com/1422-0067/21/9/3091

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