The Pseudokinase Domain of Saccharomyces cerevisiae Tra1 Is Required for Nuclear Localization and Incorporation into the SAGA and NuA4 Complexes

The Pseudokinase Domain of Saccharomyces cerevisiae Tra1 Is Required for Nuclear Localization and Incorporation into the SAGA and NuA4 Complexes

Tra1 is an essential component of the SAGA/SLIK and NuA4 complexes in S. cerevisiae, recruiting these co-activator complexes to specific promoters. As a PIKK family member, Tra1 is characterized by a C-terminal phosphoinositide 3-kinase (PI3K) domain. Unlike other PIKK family members (e.g., Tor1, To...

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Bibliographic Details
Main Authors: Matthew D. Berg, Julie Genereaux, Jim Karagiannis, Christopher J. Brandl
Format: Article
Language:English
Published: Oxford University Press 2018-06-01
Series:G3: Genes, Genomes, Genetics
Subjects:
Tra1
SAGA complex
NuA4 complex
gene expression
phosphoinositide 3-kinase (PI3K) domain
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.118.200288

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http://g3journal.org/lookup/doi/10.1534/g3.118.200288

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